Under Mauricio Pochettino this season, Spurs have tended to play three at the back, with wing backs bombing on and a dove-tailing front three. Madrid, meanwhile, are likely to again line up in the narrow 4-3-3/4-4-2 diamond that has helped them reign supreme at home and abroad in recent seasons.
As such, instead of comparing the varying quality of players deployed in different positions, Sportsmail will consider each player pound-for-pound in their respective roles before compiling an over score for each likely line-up.
Tottenham and Real Madrid clash on Wednesday two weeks on from their Bernabeu draw
Hugo Lloris vs Kiko Casilla
Hugo Lloris showed at the Bernabeu why he is such an important member of Tottenham's side, with a couple of superb reaction stops to help them earn a point.
The Frenchman then showed against Liverpool — when his indecision allowed Mohamed Salah to score — exactly why inconsistency has prevented his truly joining the elite.
Kiko Casilla, meanwhile, has had the chance to show very little at all. The 31-year-old has made only 31 appearances for Madrid since joining from Espanyol in 2015.
Hugo Lloris showed his quality during the 1-1 draw, while Kiko Casilla lacks top level experience
Wednesday night's Wembley clash will be his fifth Champions League appearance, however, highlighting his lack of top-level experience.
Lloris 8 | Casilla 6.5
Toby Alderweireld vs Achraf Hakimi
Toby Alderweireld has been the most consistent and impressive centre back in Pochettino's squad — and arguably much of the Premier League — over the last few seasons.
But the Belgium international's form has shown sings of dipping in recent weeks, notably against West Ham, thanks surely in part to his lack of consistent defensive partners.
At 18, Achraf Hakimi looks set for an immensely bright future. He, too, lacks top level experience but did impress in the return fixture at the Bernabeu.
Alderweireld 8.5 | Hakimi 6.5
Davinson Sanchez vs Sergio Ramos
Tottenham's club record signing has adjusted well to life in England and the responsibility of being the focal point of Spurs' back three.
The Colombia international has been impressive both with and without the ball. But in Sergio Ramos, Madrid have arguably one of the finest centre backs of his generation.
Still only 31, the Spain international has won it all for club and country but will be without his usual defensive partner at Wembley.
Sergio Ramos is one of the world's finest defenders, while Davinson Sanchez is still improving
Sanchez 7 | Ramos 8.5
Jan Vertonghen vs Nacho
Like Alderweireld, Jan Vertonghen has been a crucial part of the defensive solidity Spurs have established under Pochettino.
But like his former centre back partner, the Belgian has not looked as settled since moving to a back three, where his ball skills are crucial, but where his lack of mobility can be exploited.
Nacho, meanwhile, has been a growing influence for Madrid amid Raphael Varane's injury problems over recent seasons.
But he will still be considered the weaker of the two Madrid centre backs and will surely be targeted by Harry Kane or whoever leads the Spurs line.
Vertonghen 7.5 | Nacho 7
Ben Davies vs Marcelo
When fit, Ben Davies has been Pochettino's preferred left-sided defender this season. Despite a slow start to his Spurs career, the former Swansea defender has grown into a important member of their side at both ends of the pitch.
On the opposite flank, Marcelo has been a linchpin of Madrid's side for much of the past decade. The Brazilian has his critics, but he has consistently shown he is among the best full backs in the world.
Davies 7 | Marcelo 8.5
Ben Davies has improved under Mauricio Pochettino but Marcelo is among the world's best
Eric Dier vs Casemiro
Since joining Spurs, Eric Dier has been deployed at centre back, full back and in midfield and the England international's versatility has been both a blessing and a curse.
After slotting into the back three at Old Trafford, he is likely to come back into midfield against Madrid, where his positioning and ball skills will be sorely tested by Zidane's excellent midfield.
Casemiro, meanwhile, is one of the unsung heroes of this Madrid side. The 25-year-old acts an effective foil for their host of attacking talent, providing balance and stability to their midfield.
Dier 7 | Casemiro 7.5
Harry Winks vs Toni Kroos
In the absence of the injured Mousa Dembele, Harry Winks has demonstrated why he could become a crucial player for both club and country.
The 21-year-old uses the ball well and was one of Spurs stand-out players in the bear pit of the Bernabeu. But he faces a monumental task up against the imperious Toni Kroos.
Tottenham's Harry Winks faces a tough task against the imperious German Toni Kroos
Alongside Luka Modric, the Germany international has developed into one of the finest midfielders in the world. Intelligent in possession and deadly from set-pieces, he is Madrid's conductor-in-chief.
Winks 7 | Kroos 9
Serge Aurier vs Isco
Serge Aurier has enjoyed a mixed start to life in North London. Undoubtedly talented and dangerous going forward, the wing back benefits from the added defensive insurance three centre backs provide.
But ill-discipline has threatened, on occasion, to mar the early months of his Tottenham career.
Isco meanwhile, is fit despite a thigh injury forcing him off against Girona. And four goals and four assists in 15 appearances show just how crucial a role he plays for Zidane's side.
Aurier 7 | Isco 8.5
Dele Alli vs Luka Modric
Since joining from MK Dons, Dele Alli has arguably developed into the central midfield talisman that Spurs have lacked since the departure of Modric to Madrid.
Both England's Dele Alli and Luka Modric are crucial to the creativity of their respective sides
The England international has already netted five goals and picked up one assist this season as he continues his staggering improvement under Pochettino.
Modric, meanwhile, is no longer the illusive playmaker he was in North London. The 32-year-old has moved into a deeper role for the La Liga giants. But his ball skills and intelligence in possession have never deserted him.
Alli 8.5 vs Modric 9
Christian Eriksen vs Karim Benzema
Two different players with equally important roles for their teams. Christian Eriksen's excellent eye for a pass and delivery from dead balls make him the perfect complement for the all-action pair of Alli and Kane.
Contrastly, France international Benzema has been the attacking focal point for Madrid for a number of years. Despite the array of talent that has come and gone at the Bernabeu, Benzema has been a constant. And a constant source of goals.
Eriksen 8.5 | Benzema 8
Harry Kane vs Cristiano Ronaldo
Both Harry Kane and Cristiano Ronaldo have been a constant source of goals for their sides
The level of optimism among Tottenham fans heading up Wembley way on Wednesday night will depend greatly on whether Kane is declared fit. Though Spurs are far from a one-man team, the England international has been prolific for the past three-and-a-bit seasons.
Likewise, Cristiano Ronaldo's goals have been crucial in helping Madrid conquer at home and abroad under Zidane. He now operates much more within the width of the penalty area than he did in his early years in Spain. But his eye for goal has never wavered.
Kane 9.5 | Ronaldo 9.5
TEAM TOTALS: Tottenham 85.5 | Real Madrid 88.5